Inositol-tetrakisphosphate 5-kinase

In enzymology, an inositol-tetrakisphosphate 5-kinase (EC 2.7.1.140) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate ${\displaystyle \rightleftharpoons }$ ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

inositol tetrakisphosphate 5-kinase
Identifiers
EC no.	2.7.1.140
CAS no.	123940-40-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,3,4,6-tetrakisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase. This enzyme is also called 1D-myo-inositol-tetrakisphosphate 5-kinase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.