Kynurenine—glyoxylate transaminase

In enzymology, a kynurenine-glyoxylate transaminase (EC 2.6.1.63) is an enzyme that catalyzes the chemical reaction:

L-kynurenine + glyoxylate ${\displaystyle \rightleftharpoons }$ 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine

kynurenine-glyoxylate transaminase
Identifiers
EC no.	2.6.1.63
CAS no.	74506-33-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are L-kynurenine and glyoxylate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and glycine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:glyoxylate aminotransferase (cyclizing). This enzyme is also called kynurenine-glyoxylate aminotransferase.