LETM1-like protein family

LETM1-like is a family of evolutionarily related proteins. This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,^[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.^[1] A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster,^[2] suggesting that this may be a group of mitochondrial proteins.

LETM1
Identifiers
Symbol	LETM1
Pfam	PF07766
InterPro	IPR011685
TCDB	8.A.20
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Examples

Human gene encoding members of this family include:

• LETM1, LETM2, LETMD1