LPAR2

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene.^[5][6][7] LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

LPAR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P0C
Identifiers
Aliases	LPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs	OMIM: 605110; MGI: 1858422; HomoloGene: 3465; GeneCards: LPAR2; OMA:LPAR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 19,623,655 bp[1] End 19,628,930 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.3|8 33.91 cM Start 70,275,079 bp[2] End 70,283,752 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone granulocyte blood right testis spleen left testis monocyte mucosa of transverse colon right lung Top expressed in granulocyte yolk sac epiblast tail of embryo otic vesicle genital tubercle ventricular zone ganglion of vagus nerve primitive streak placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding protein binding lysophosphatidic acid receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of plasma membrane membrane endocytic vesicle integral component of membrane plasma membrane cell surface Biological process activation of phospholipase C activity signal transduction positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9170 53978 Ensembl ENSG00000064547 ENSMUSG00000031861 UniProt Q9HBW0 Q9JL06 Q6P290 RefSeq (mRNA) NM_004720 NM_001395660 NM_020028 RefSeq (protein) NP_004711 NP_064412 Location (UCSC) Chr 19: 19.62 – 19.63 Mb Chr 8: 70.28 – 70.28 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.^[5]

Interactions

LPAR2 has been shown to interact with TRIP6.^[9]

Evolution

Paralogues

Source:^[10][11]

• LPAR1
• LPAR3
• S1PR1
• S1PR5
• S1PR4
• S1PR2
• S1PR3
• GPR6
• GPR3
• GPR12
• MC4R
• MC5R
• CNR1
• MC3R
• CNR2
• MC1R
• GPR119
• MC2R

See also

• Lysophospholipid receptor