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Lateral body
From Wikipedia, the free encyclopedia
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Lateral bodies are structures that sit on the concave sides of the viral core of a poxvirus and is surrounded by a membrane.[1] They serve as immunomodulatory delivery packets, and membrane cloaking to spread poxviruses.[2] They were first visualized using electron microscopy in 1956 and shortly after, it was shown that they detach from the viral core upon membrane fusion.[3][4]
Lateral body proteins
Lateral bodies are made up of at least three proteins, phosphoprotein F17, dual-specificity phosphatase H1 and the viral oxidoreductase G4.[5] F17 is the main structural protein and may play a role in modulating cellular immune response through MAPK signaling pathways.[6] H1 dephosphorylates STAT1 to prevent nuclear transcription and block IFNy-induced immune signaling.[5] Finally, G4 is essential for viral morphogenesis.[5] Additionally, the proteins packed in lateral bodies are redox proteins, which modulates the host oxidative response impacting early gene expression and virion production.[7]
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References
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