Laudexium metilsulfate

Laudexium metilsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Laudexium metilsulfate

Clinical data
Other names	Laudolissin
Routes of administration	IV
Legal status
Legal status	discontinued from clinical use
Pharmacokinetic data
Bioavailability	100% (IV)
Identifiers
IUPAC name 1-[(3,4-Dimethoxyphenyl)methyl]-2-[10-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]decyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium methyl sulfate
CAS Number	3253-60-9 Y
PubChem CID	18618
ChemSpider	17584 N
UNII	D067KDG4NU
CompTox Dashboard (EPA)	DTXSID301029355
Chemical and physical data
Formula	C54H80N2O16S2
Molar mass	1077.35 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCCCCCCCCC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.COS(=O)(=O)[O-].COS(=O)(=O)[O-]
InChI InChI=1S/C52H74N2O8.2CH4O4S/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44H,11-18,23-30H2,1-10H3;2*1H3,(H,2,3,4)/q+2;;/p-2 N Key:LADQAYSLFLCKOD-UHFFFAOYSA-L N
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Laudexium^[1] is no longer used in clinical practice, though it was introduced clinically in the early 1950s.^{[citation needed]} It has about half the potency, a slower onset of action and a duration of action much longer than that of d-tubocurarine.^[2] As with all clinically established (as well as experimental agents) with a non-depolarizing mechanism of action, its pharmacological action can be antagonized by anticholinesterases.

The displacement of laudexium from clinical use was assured owing to recurrent reports of significant post-operative re-curarization.^[3]