| Title | Director | Cast | Genre | Notes |
| 2000 |
| 20 - Venti | Marco Pozzi | Anita Caprioli, Cecilia Dazzi | comedy-drama | |
| Against the Wind (Controvento) | Peter Del Monte | Margherita Buy, Valeria Golino, Ennio Fantastichini | Drama | |
| All the Love There Is (Tutto l'amore che c'è) | Sergio Rubini | Damiano Russo, Vittoria Puccini, Margherita Buy, Sergio Rubini, Gérard Depardieu | Drama | |
| Almost Blue | Alex Infascelli | Lorenza Indovina, Andrea Di Stefano, Claudio Santamaria | thriller | |
| Body Guards - Guardie del corpo | Neri Parenti | Christian De Sica, Massimo Boldi, Cindy Crawford | Comedy | |
| Bread and Tulips (Pane e tulipani) | Silvio Soldini | Licia Maglietta, Bruno Ganz, Giuseppe Battiston, Marina Massironi | Comedy | 9 David di Donatello. 5 Nastro d'Argento |
| Canone inverso | Ricky Tognazzi | Hans Matheson, Mélanie Thierry, Gabriel Byrne | Drama | Five David di Donatello (Best Cinematography, Best Editing, Best Production Design, Best Score and a special "Scuola David Award"), three Silver Ribbons (Best Cinematography, Best Editing and Best Score), Best Feature Film award and Audience Award for Best Feature at 2001 Newport Beach Film Festival. |
| La Carbonara | Luigi Magni | Lucrezia Lante della Rovere, Valerio Mastandrea, Nino Manfredi, Pierfrancesco Favino | historical comedy-drama | |
| Denti | Gabriele Salvatores | Sergio Rubini, Anita Caprioli, Paolo Villaggio, Fabrizio Bentivoglio | comedy-drama | entered the 57th Venice Film Festival |
| Fantozzi 2000 – La clonazione | Domenico Saverni | Paolo Villaggio, Milena Vukotic, Anna Mazzamauro | Comedy | |
| First Light of Dawn | Lucio Gaudino | Laura Morante, Gianmarco Tognazzi | drama | entered the 50th Berlin Film Festival |
| Free the Fish | Cristina Comencini | Michele Placido, Laura Morante | Comedy | |
| Freewheeling | Vincenzo Salemme | Vincenzo Salemme, Sabrina Ferilli | Comedy | |
| Golem | Louis Nero | Moni Ovadia | Drama | |
| Gostanza da Libbiano | Paolo Benvenuti | Lucia Poli | Drama | |
| Holy Tongue | Carlo Mazzacurati | Antonio Albanese, Fabrizio Bentivoglio, Isabella Ferrari | comedy | entered the 57th Venice Film Festival |
| Io amo Andrea | Francesco Nuti | Francesco Nuti, Francesca Neri, Agathe de La Fontaine | romantic comedy | |
| I Prefer the Sound of the Sea | Mimmo Calopresti | Silvio Orlando, Andrea Occhipinti | drama | Screened at the 2000 Cannes Film Festival |
| Johnny the Partisan | Guido Chiesa | Stefano Dionisi, Fabrizio Gifuni, Claudio Amendola | war-drama | entered the 57th Venice Film Festival |
| Joseph of Nazareth | Raffaele Mertes | Tobias Moretti, Ennio Fantastichini, Ida Di Benedetto | Biblical | |
| Malèna | Giuseppe Tornatore | Monica Bellucci, Giuseppe Sulfaro, Luciano Federico | Drama | 2 Academy Award nominations |
| Mirka | Rachid Benhadj | Vanessa Redgrave, Gérard Depardieu, Sergio Rubini, Franco Nero | drama | |
| Nightwatchman | Francesco Calogero | Diego Abatantuono, Marco Messeri | thriller | |
| Una noche con Sabrina Love | Alejandro Agresti | Cecilia Roth, Tomás Fonzi, Giancarlo Giannini | comedy-drama | |
| I nostri anni | Daniele Gaglianone | - | Documentary | |
| One Hundred Steps | Marco Tullio Giordana | Luigi Lo Cascio, Luigi Maria Burruano, Tony Sperandeo | Drama | 4 David di Donatello |
| Picasso's Face | Massimo Ceccherini | Massimo Ceccherini, Alessandro Paci, Marco Giallini | Comedy | |
| Placido Rizzotto | Pasquale Scimeca | Marcello Mazzarella, Vincenzo Albanese, Carmelo Di Mazzarelli | Drama | |
| The Prince's Manuscript | Roberto Andò | Michel Bouquet, Jeanne Moreau | biographical drama | |
| Rosa and Cornelia | Giorgio Treves | Stefania Rocca, Chiara Muti, Athina Cenci | drama | |
| Scarlet Diva | Asia Argento | Asia Argento, Jean Shepard, Selen | Erotic drama | |
| This Is Not Paradise | Gianluca Maria Tavarelli | Fabrizio Gifuni, Valerio Binasco | Crime | |
| Titanic: The Legend Goes On | Camillo Teti | Mickey Knox, Edmund Purdom | Animation | |
| Zora the Vampire | Manetti Bros | Micaela Ramazzotti, Toni Bertorelli, Carlo Verdone, Valerio Mastandrea | horror-comedy | based on the eponymous comic |
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