This list is arranged by drainage basin, from north to south, with respective tributaries indented under each larger stream's name. All rivers in South Carolina drain to the Atlantic Ocean.

Little River
Pee Dee River
- Old Dead River
- Sampit River
- Black River
  - Black Mingo Creek
  - Pocotaligo River
- Little Pee Dee River
  - Lumber River
- Lynches River
  - Little River
- Jeffries Creek
- Black Creek

Santee River (North Santee River and South Santee River are distributaries)
- Little River
- Wateree River
  - Catawba River
    - Fishing Creek
- Congaree River
  - Dead River
  - Old Dead River
  - Broad River
  - Saluda River
    - Little Saluda River
    - Bush River
    - Little River
    - Reedy River
    - North Saluda River
    - Middle Saluda River
    - South Saluda River
      - Oolenoy River
  - Gills Creek

Thumb — Rivers flowing to Charleston Harbor

Edisto River (North Edisto River and South Edisto River are distributaries)
- Four Holes Swamp
- North Fork Edisto River
  - Bull Swamp Creek
- South Fork Edisto River
  - Little River
Ashepoo River
Combahee River
- Little Salkehatchie River
- Salkehatchie River
Coosaw River
Morgan River (SC)
Story River
Beaufort River
Broad River
- Colleton River
- Pocotaligo River
- Coosawhatchie River
  - Tulifiny River
May River
New River
Wright River

Savannah River

By drainage basin

Alphabetically

See also

References