Long-chain-fatty-acid—luciferin-component ligase

In enzymology, a long-chain-fatty-acid—luciferin-component ligase (EC 6.2.1.19) is an enzyme that catalyzes the chemical reaction

ATP + an acid + protein ${\displaystyle \rightleftharpoons }$ AMP + diphosphate + an acyl-protein thioester

Long-chain-fatty-acid—luciferin-component ligase
Identifiers
EC no.	6.2.1.19
CAS no.	82657-98-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, acid, and protein, whereas its 3 products are AMP, diphosphate, and acyl-protein thioester.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:protein ligase (AMP-forming). This enzyme is also called acyl-protein synthetase.