Loperamide/simethicone

Loperamide/simethicone is combination medication sold under the brand name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. It contains loperamide and simethicone.

Loperamide/simethicone

Combination of
Loperamide	Antidiarrheal
Simethicone	Gas reducer
Clinical data
Trade names	Imodium Multi-Symptom Relief, Imodium Plus, Imodium Plus Comfort
License data	US DailyMed: Loperamide and simethicone
Pregnancy category	AU: B3
Routes of administration	By mouth
ATC code	A07DA53 (WHO)
Legal status
Legal status	UK: P (Pharmacy medicines) / GSL US: OTC

Loperamide is a μ-opioid receptor agonist that works in the intestines.^[1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen.

Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects.^[2][3]