3,4-Methylenedioxyphentermine

3,4-Methylenedioxyphentermine (MDPH) is a psychoactive drug of the amphetamine family. MDPH was first synthesized by Alexander Shulgin.^[1] Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPH.^[1]

MDPH

Clinical data
Other names	MDP; MDPH; 3,4-Methylenedioxyphentermine; 3,4-Methylenedioxy-α,α-dimethylphenethylamine
Routes of administration	Oral[1]
Drug class	Psychoactive drug
ATC code	None
Pharmacokinetic data
Duration of action	3–5 hours[1]
Identifiers
IUPAC name 1-(2H-1,3-benzodioxol-5-yl)-2-methylpropan-2-amine
CAS Number	39235-63-7 Y
PubChem CID	13020598
ChemSpider	15204207 Y
UNII	WF9K2PM8J8
ChEMBL	ChEMBL126226
CompTox Dashboard (EPA)	DTXSID90515395
Chemical and physical data
Formula	C11H15NO2
Molar mass	193.246 g·mol−1
3D model (JSmol)	Interactive image
SMILES NC(C)(C)CC1=CC(OCO2)=C2C=C1
InChI InChI=1S/C11H15NO2/c1-11(2,12)6-8-3-4-9-10(5-8)14-7-13-9/h3-5H,6-7,12H2,1-2H3 N Key:OIZBHKBNZXRXSM-UHFFFAOYSA-N N
NY (what is this?)  (verify)

Use and effects

In his book PiHKAL (Phenethylamines i Have Known And Loved), the dose range is listed as 160–240 mg, and the duration as 3 to 5 hours.^[1] MDPH's effects are very similar to those of MDA: they both are smooth and "stoning," and do not cause any visuals.^[1] They also alter dreams and dream patterns.^[1] But it is said to have none of the magic of MDMA.^[1] Shulgin describes MDPH as a promoter; it promotes the effects of other drugs, similarly to 2C-D.^[1]

Chemistry

Synthesis

The chemical synthesis of MDPH has been described.^[1]

Analogues

The N-methyl derivative, 3,4-methylenedioxy-N-methylphentermine (MDMPH), has been described by Shulgin as lacking MDMA-like effects.^[2] Accordingly, MDMPH, as well as MDPH, were found to be inactive as serotonin releasing agents in vitro.^[2][3]

Society and culture

Legal status

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.^[4]

See also

• Substituted methylenedioxyphenethylamine
• 3,4-Dichloroamphetamine
• Cericlamine
• Chlorphentermine
• Cloforex
• Clortermine
• Etolorex
• Methylenedioxyphenmetrazine
• Phentermine