MYO5B

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.^[5][6][7][8]

MYO5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J5M, 4LNZ, 4LWZ, 4LX0
Identifiers
Aliases	MYO5B, myosin VB, MVID1, DIAR2, PFIC10
External IDs	OMIM: 606540; MGI: 106598; HomoloGene: 49481; GeneCards: MYO5B; OMA:MYO5B - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.1 Start 49,822,789 bp[1] End 50,195,147 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 E2|18 50.7 cM Start 74,574,007 bp[2] End 74,904,564 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum jejunal mucosa pancreatic ductal cell rectum mucosa of transverse colon duodenum islet of Langerhans mucosa of sigmoid colon nasal epithelium palpebral conjunctiva Top expressed in primary oocyte dentate gyrus of hippocampal formation granule cell zygote secondary oocyte jejunum ileum epithelium of lens intestinal epithelium epithelium of small intestine transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding calmodulin binding microfilament motor activity protein binding actin binding cytoskeletal motor activity ATP binding actin filament binding Cellular component cytoplasm recycling endosome apical cortex extracellular exosome cytoplasmic vesicle membrane myosin complex protein-containing complex Biological process renal water homeostasis protein transport vesicle-mediated transport transport endosomal transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4645 17919 Ensembl ENSG00000167306 ENSMUSG00000025885 UniProt Q9ULV0 P21271 RefSeq (mRNA) NM_001080467 NM_008661 NM_201600 RefSeq (protein) NP_001073936 n/a Location (UCSC) Chr 18: 49.82 – 50.2 Mb Chr 18: 74.57 – 74.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Recent evidence suggests that Myosin-Vb is related to the creation of memories^[9] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.^[10]

Mutations of MYO5B cause microvillus inclusion disease due to defective trafficking of apical and basolateral proteins.^[8]

MYO5B has also been associated with bipolar disorder.^[11]

Interactions

MYO5B has been shown to interact with RAB11FIP2.^[12]