Maleylpyruvate isomerase

In enzymology, a maleylpyruvate isomerase (EC 5.2.1.4) is an enzyme that catalyzes the chemical reaction

3-maleylpyruvate ${\displaystyle \rightleftharpoons }$ 3-fumarylpyruvate

maleylpyruvate isomerase
Identifiers
EC no.	5.2.1.4
CAS no.	9023-77-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, 3-maleylpyruvate, and one product, 3-fumarylpyruvate.

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 3-maleylpyruvate cis-trans-isomerase. This enzyme participates in tyrosine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2NSF and 2NSG.