Meprin A

Meprin A (EC 3.4.24.18, endopeptidase-2, meprin-a, meprin, N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA-peptide hydrolase, PPH) is an enzyme that cleaves protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.^[1] This metalloprotease can be associated with inflammatory responses.^[2] It can be found in the extracellular space where it can also form complex structures by joining its monomers together.^[2]

Meprin A
Identifiers
EC no.	3.4.24.18
CAS no.	148938-24-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Meprin A
Identifiers
Symbol	Meprin
InterPro	IPR008294
Membranome	537

Meprin A is a dimer composed of the products transcribed from the following two genes:

meprin A, alpha Identifiers Symbol MEP1A NCBI gene 4224 HGNC 7015 OMIM 600388 RefSeq NM_005588 UniProt Q16819 Other data EC number 3.4.24.18 Locus Chr. 6 p12-p11 Search for Structures Swiss-model Domains InterPro

meprin A, beta Identifiers Symbol MEP1B NCBI gene 4225 HGNC 7020 OMIM 600389 RefSeq NM_005925 UniProt Q16820 Other data EC number 3.4.24.18 Locus Chr. 18 q12.2-12.3 Search for Structures Swiss-model Domains InterPro