Methionyl-tRNA formyltransferase

In enzymology, a methionyl-tRNA formyltransferase (EC 2.1.2.9) is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + L-methionyl-tRNA^fMet + H₂O ${\displaystyle \rightleftharpoons }$ tetrahydrofolate + N-formylmethionyl-tRNA^fMet

Methionyl-tRNA formyltransferase
Structure of Fmt in Escherichia coli
Identifiers
EC no.	2.1.2.9
CAS no.	9015-76-3
Alt. names	N10-formyltetrahydrofolic-methionyl-transfer ribonucleic, transformylase, formylmethionyl-transfer ribonucleic synthetase, methionyl ribonucleic formyltransferase, methionyl-tRNA Met formyltransferase, methionyl-tRNA transformylase, methionyl-transfer RNA transformylase, methionyl-transfer ribonucleate methyltransferase, methionyl-transfer ribonucleic transformylase
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. This enzyme participates in three metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1FMT and 2FMT.