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Oxford Nanopore Technologies
U.K.-based nanopore sequencing company From Wikipedia, the free encyclopedia
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Oxford Nanopore Technologies plc is a UK-based company which develops and sells nanopore sequencing products (including the portable DNA sequencer, MinION) for the direct, electronic analysis of single molecules.[2][3][4] It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index.[5]
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History
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The company was founded in 2005 as a spin-out from the University of Oxford by Hagan Bayley,[6] Gordon Sanghera, and Spike Willcocks, with seed funding from the IP Group.[7] The company made an initial public offering on the London Stock Exchange on 30 September 2021, under the ticker ONT.[8]
In March 2016 the company announced a chemistry upgrade to its nanopore sequencing product 'R9', using a protein nanopore in collaboration with the laboratory of Han Remaut (VIB/Vrije Universiteit Brussel).[9] The company stated in a webcast that R9 is designed to improve error rates and yield.[10]
In July 2016, a MinION nanopore sequencer was included on the ninth NASA/SpaceX commercial cargo resupply services mission to the International Space Station.[11] The aim of the mission was to provide proof of concept for the MinION's functionality in a microgravity environment.[12] During the mission, ISS crew members successfully sequenced DNA from bacteria, bacteriophage and rodents from samples prepared on Earth.[13] Maintaining the MinION device as a research facility on the space station holds the potential to support a number of additional science investigations, any of which could have Earth based applications.[14]
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Products
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The main products of Oxford Nanopore are:
- MinION:[3][15][16] this harmonica-sized portable protein nanopore sequencing USB device has been commercially available since May 2015[17] after having been launched initially through an early access program, the MinION Access Program (MAP).[18]
- GridION X5: this desktop device has been commercially available since March 2017.[19] The device processes up to five MinION Flow Cells and enables generation of up to 100 Gb of data per run.[20]
- PromethION: this desktop, high throughput device will be available through an access program[21] that opened for registration in July 2015. The device contains channels for 144,000 nanopores (in comparison to MinION’s 512).[22]
- VolTRAX: this device is designed for automated library preparation so that users do not need a laboratory or lab skills to run the device.[23] Registration for the early access program was opened in October 2016.[24]
- Metrichor: this spinout company from Oxford Nanopore was set up to provide end to end solutions for biological analyses, using nanopore sensing technologies.[25][26]
- SmidgION: a mobile phone sequencer announced in May 2016, currently in development.[27]
These products are intended to be used for the analysis of DNA, RNA, proteins and small molecules with a range of applications in personalized medicine, crop science, and scientific research.[3][28]
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