Mir-192/215 microRNA precursor

The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNA gene involved in gene regulation. miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.^[1][2]

mir-192/215 microRNA precursor
Predicted secondary structure and sequence conservation of mir-192
Identifiers
Symbol	mir-192
Rfam	RF00130
miRBase	MI0000234
miRBase family	MIPF0000063
Other data
RNA type	Gene; miRNA
Domain(s)	Eukaryota
GO	GO:0035195 GO:0035068
SO	SO:0001244
PDB structures	PDBe

microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.^[3]

mir-192 and mir-215 are overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets.^[4] It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.^[5]

miR-215 and miR-192 are also both implicated in major depressive disorder. Small-RNA sequencing reveals upregulated expression for both miR-215 and miR-192 in the synaptosomes derived from the dorsolateral prefrontal cortex of MDD subjects.^[6]