Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

Mn²⁺-dependent ADP-ribose/CDP-alcohol diphosphatase (EC 3.6.1.53, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, ADPRibase-Mn) is an enzyme with systematic name CDP-choline phosphohydrolase.^[1][2] This enzyme catalyses the following chemical reaction

(1) CDP-choline + H₂O ${\displaystyle \rightleftharpoons }$ CMP + phosphocholine

(2) ADP-ribose + H₂O ${\displaystyle \rightleftharpoons }$ AMP + D-ribose 5-phosphate

Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
Identifiers
EC no.	3.6.1.53
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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This enzyme requires Mn²⁺, which cannot be replaced by Mg²⁺.