Monokine

A monokine is a type of cytokine^[1] produced primarily by monocytes and macrophages.

Some monokines are:

• interleukin 1^[2]
• tumor necrosis factor-alpha^[2]
• alpha and beta interferon^[3]
• colony stimulating factors ^[3]

Functions

Monokines released from macrophages can attract neutrophils, via the process chemotaxis.

The secretion of monokine, prompted by interferon gamma, has activity for the receptors found within immune cells, such as T-cells, hindering their ability to function as regulators of the body. Thus, promoting tumor progression in the cancer-state.^[4] In fact, its activity is important in other diseases, such as pulmonary tuberculosis, where researchers have identified monokine as a biomarker.^[5]

See also

• Lymphokine