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Murid gammaherpesvirus 68
Virus isolate From Wikipedia, the free encyclopedia
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Murid gammaherpesvirus 68 (MuHV-68) is an isolate of the virus species Murid gammaherpesvirus 4, a member of the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family of Herpesviridae. MuHV-68 serves as a model for study of human gammaherpesviruses which cause significant human disease including B-cell lymphoma and Kaposi's sarcoma. The WUMS strain of MuHV-68 was fully sequenced and annotated in 1997,[1] and the necessity of most of its genes in viral replication was characterized by random transposon mutagenesis.[2]
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Surface proteins
Alpha-, beta-, and gammaherpesviruses display a heterodimer composed of glycoprotein H (gH) and glycoprotein L (gL) on their envelopes. This receptor is involved in the cell-to-cell transmission of the virus. Glycoprotein H has two conformations. Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. Murid gammaherpesvirus 68 lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. Murid gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells.[3]
The open reading frame M7 of the MuHV-68 genome encodes for the surface receptor glycoprotein 150 (gp150). It is homologous to the Epstein-Barr virus membrane antigen gp350/220.[4] MuHV-68 is more closely related to the Kaposi's sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus. Glycoprotein K8.1 is the KSHV homolog of MuHV-68 gp150.[5] MuHV-68 is a very close relative of MuHV-72. The MuHV-68 M7 gene differs from the corresponding MuHV-72 gene by five point mutations which alter four codons.[4] Glycoprotein 150 allows MuHV-68 to bind to B-cells.[5]
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References
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