Mycobacterium intermedium

Mycobacterium intermedium is a species of the phylum Actinomycetota (Gram-positive bacteria with high guanine and cytosine content, one of the dominant phyla of all bacteria), belonging to the genus Mycobacterium.

Mycobacterium intermedium
Scientific classification
Domain:	Bacteria
Kingdom:	Bacillati
Phylum:	Actinomycetota
Class:	Actinomycetia
Order:	Mycobacteriales
Family:	Mycobacteriaceae
Genus:	Mycobacterium
Species:	M. intermedium
Binomial name
Mycobacterium intermedium Meier et al. 1993, ATCC 51848

Etymology: Latin; intermedium, meaning between, rapidly and slowly growing mycobacteria.

Description

Gram-positive, and nonmotile acid-fast coccobacilli (2.0 μm x 2.6 μm).

Colony characteristics

• Eugonic, smooth and photochromogenic colonies (3–5mm in diameter) on Löwenstein-Jensen medium.

Physiology

• Growth on Löwenstein-Jensen medium at 22 °C, 31 °C, 37 °C and 41 °C, (optimal temperature between 31 °C and 37 °C), within 2–3 weeks.
• Susceptible to ethambutol and rifampin.
• Resistant to isoniazid and streptomycin.

Differential characteristics

• Phylogenetic position between rapidly and slowly growing mycobacteria.
• M. asiaticum is phenotypically very similar, but can be distinguished by its growth at 22 °C, and by its dysgonic growth.

Pathogenesis

• Pulmonary disease
• Biosafety level 2

Type strain

• Repeatedly isolated from sputum from a patient with pulmonary disease.

Strain 1669/91 = ATCC 51848 = CCUG 37583 = CIP 104542 = DSM 44049 = JCM 13572