Mycocerosate synthase

In enzymology, a mycocerosate synthase (EC 2.3.1.111) is an enzyme that catalyzes the chemical reaction

long-chain acyl-[mycocerosate synthase] + n methylmalonyl-CoA + 2n NADPH + 2n H⁺ ${\displaystyle \rightleftharpoons }$ multi-methyl-branched acyl-[mycocerosate synthase] + n CoA + n CO₂ + 2n NADP⁺

mycocerosate synthase
Identifiers
EC no.	2.3.1.111
CAS no.	95229-19-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 4 substrates of this enzyme are acyl-CoA, methylmalonyl-CoA, NADPH, and H⁺, whereas its 4 products are multi-methyl-branched acyl-[mycocerosate synthase], CoA, CO₂, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). This enzyme is also called mycocerosic acid synthase.