N-acetylhexosamine 1-dehydrogenase

In enzymology, a N-acetylhexosamine 1-dehydrogenase (EC 1.1.1.240) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine + NAD⁺ ${\displaystyle \rightleftharpoons }$ N-acetyl-D-glucosaminate + NADH + H⁺

N-acetylhexosamine 1-dehydrogenase
Identifiers
EC no.	1.1.1.240
CAS no.	122785-18-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and NAD⁺, whereas its 3 products are N-acetyl-D-glucosaminate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is N-acetyl-D-hexosamine:NAD⁺ 1-oxidoreductase. Other names in common use include N-acetylhexosamine dehydrogenase, and N-acetyl-D-hexosamine dehydrogenase.