NAD(P)+ transhydrogenase (Re/Si-specific)

In enzymology, a NAD(P)⁺ transhydrogenase (Re/Si-specific (EC 1.6.1.2) is an enzyme that catalyzes the chemical reaction

NADPH + NAD⁺ ${\displaystyle \rightleftharpoons }$ NADP⁺ + NADH

NAD(P) transhydrogenase
NAD(P) transhydrogenase heterotrimer, Rhodospirillum rubrum
Identifiers
Symbol	?
Pfam	PF02233
TCDB	3.D.2
OPM superfamily	410
OPM protein	4o9u
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

NAD(P)+ transhydrogenase (Re/Si-specific
Identifiers
EC no.	1.6.1.2
CAS no.	9014-18-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are NADPH and NAD⁺, whereas its two products are NADP⁺ and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with NAD+ or NADP+ as acceptor. This enzyme participates in nicotinate and nicotinamide metabolism.

Nomenclature

The systematic name of this enzyme class is NADPH:NAD+ oxidoreductase (Re/Si-specific). Other names in common use include pyridine nucleotide transhydrogenase, transhydrogenase, NAD(P)+ transhydrogenase, nicotinamide adenine dinucleotide (phosphate) transhydrogenase, NAD+ transhydrogenase, NADH transhydrogenase, nicotinamide nucleotide transhydrogenase, NADPH-NAD+ transhydrogenase, pyridine nucleotide transferase, NADPH-NAD+ oxidoreductase, NADH-NADP+-transhydrogenase, NADPH:NAD+ transhydrogenase, H+-Thase, energy-linked transhydrogenase, and NAD(P)+ transhydrogenase (AB-specific).