NDST3

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.^[5][6] It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)^[7]

NDST3
Identifiers
Aliases	NDST3, HSST3, N-deacetylase/N-sulfotransferase 3, N-deacetylase and N-sulfotransferase 3
External IDs	OMIM: 603950; MGI: 1932544; HomoloGene: 3513; GeneCards: NDST3; OMA:NDST3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 118,033,618 bp[1] End 118,258,634 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 123,319,815 bp[2] End 123,484,502 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell cerebellar cortex cerebellar hemisphere testicle right hemisphere of cerebellum prefrontal cortex ganglionic eminence nucleus accumbens Brodmann area 9 right frontal lobe Top expressed in cerebellar cortex spermatid primary visual cortex seminiferous tubule superior frontal gyrus lumbar subsegment of spinal cord neural layer of retina inferior colliculi dentate gyrus of hippocampal formation granule cell cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity catalytic activity hydrolase activity [heparan sulfate-glucosamine N-sulfotransferase activity] heparan sulfate N-acetylglucosaminyltransferase activity deacetylase activity heparan sulfate sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane cellular component Biological process metabolism heparin biosynthetic process heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process glycosaminoglycan biosynthetic process sulfur compound metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9348 83398 Ensembl ENSG00000164100 ENSMUSG00000027977 UniProt O95803 Q9EQH7 RefSeq (mRNA) NM_004784 NM_001293682 NM_031186 RefSeq (protein) NP_004775 NP_001280611 NP_112463 Location (UCSC) Chr 4: 118.03 – 118.26 Mb Chr 3: 123.32 – 123.48 Mb PubMed search [3] [4]
Wikidata
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This is a step in the production of heparin.^[7]

Clinical significance

Mutations in NDST3 have been linked to schizophrenia.^[8]