Neuropeptide Y receptor

Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.^[1] These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.^{[2][3][4][5][6][7]}

neuropeptide Y receptor Y1
Identifiers
Symbol	NPY1R
Alt. symbols	NPYR
NCBI gene	4886
HGNC	7956
OMIM	162641
RefSeq	NM_000909
UniProt	P25929
Other data
Locus	Chr. 4 q31.3-q32
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neuropeptide Y receptor Y2
Identifiers
Symbol	NPY2R
NCBI gene	4887
HGNC	7957
OMIM	162642
RefSeq	NM_000910
UniProt	P49146
Other data
Locus	Chr. 4 q31
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pancreatic polypeptide receptor 1
Identifiers
Symbol	PPYR1
Alt. symbols	NPY4R, Y4, PP1
NCBI gene	5540
HGNC	9329
OMIM	601790
RefSeq	NM_005972
UniProt	P50391
Other data
Locus	Chr. 10 q11.2
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neuropeptide Y receptor Y5
Identifiers
Symbol	NPY5R
NCBI gene	4889
HGNC	7958
OMIM	602001
RefSeq	NM_006174
UniProt	Q15761
Other data
Locus	Chr. 4 q31-q32
Search for Structures Swiss-model Domains InterPro

Activated neuropeptide receptors release the G_i subunit from the heterotrimeric G protein complex. The G_i subunit in turn inhibits the production of the second messenger cAMP from ATP.

Only the crystal structure of Y1 in complex with two antagonist is available.^[8]

Types

There are five known mammalian neuropeptide Y receptors designated Y₁ through Y₅.^[9] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.^[10][11][12]

• Y₁ - NPY1R
• Y₂ - NPY2R
• Y₄ - PPYR1
• Y₅ - NPY5R

Antagonists

• BIBP-3226
• Lu AA-33810
• BIIE-0246
• UR-AK49