Talaporfin

Talaporfin (INN, also known as aspartyl chlorin, mono-L-aspartyl chlorin e6, NPe6, or LS11) is a chlorin based photosensitizer used in photodynamic therapy (PDT).

Talaporfin

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name N-{[(2S,3S)-7-carboxy-3-(2-carboxyethyl)-12-ethyl-2,8,13,18-tetramethyl-17-vinyl-2,3-dihydroporphyrin-5-yl]acetyl}-L-aspartic acid
CAS Number	110230-98-3 Y 220201-34-3 (sodium salt)
PubChem CID	5486799
ChemSpider	16737134 N
UNII	P4ROX5ELT2
CompTox Dashboard (EPA)	DTXSID101318471
Chemical and physical data
Formula	C38H41N5O9
Molar mass	711.772 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC1=C2C=C3C(=C(C(=N3)C(=C4[C@H]([C@@H](C(=N4)C=C5C(=C(C(=CC(=C1C)N2)N5)C=C)C)C)CCC(=O)O)CC(=O)N[C@@H](CC(=O)O)C(=O)O)C(=O)O)C
InChI InChI=1S/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39,43H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/b24-12-,25-13-,26-12-,27-14-,28-13-,29-14-,35-23-,36-23-/t18-,22-,30-/m0/s1 N Key:VSEIDZLLWQQJGK-WSUYNKMOSA-N N
NY (what is this?)  (verify)

It absorbs red light at 664-667 nm normally provided by a laser tuned to this wavelength.^[1]

It was approved in Japan (in 2004) for PDT of lung cancer and marketed as Laserphyrin.^[2]