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Naproxen/diphenhydramine
Drug combination used to relieve pain for sleep. Harmful to fetus in third trimester of pregnancy. From Wikipedia, the free encyclopedia
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Naproxen/diphenhydramine (trade name Aleve PM) is a formulation of naproxen with diphenhydramine marketed by Bayer Healthcare.[1] It is made as an over-the-counter drug. The intended use of the drug is relieve pain specifically when going to sleep.[2]
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Adverse effects
Women in the third trimester of pregnancy should avoid this drug because there is a risk that naproxen, like other NSAIDs, may cause premature closure of the ductus arteriosus.[2]
In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[3][4] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[3][4]
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References
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