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Nitroxinil

Chemical compound From Wikipedia, the free encyclopedia

Nitroxinil
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Nitroxinil is an anthelmintic, a veterinary medicine against parasitic worms in sheep and cattle.[1] The substance is active against the liver fluke the Fasciola hepatica and to a lesser extent against thread worms in the gastrointestinal tract.[2] Brand names include Fluconix, Dovenix and Trodax. Nitroxynil is also used against strains of the red gum worm (Haemonchus contortus) that have become resistant to benzimidazoles.[citation needed]

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Nitroxinil was invented by May & Baker[3] in the mid 1960s as part of a program into investigation of derivatives of p-hydroxybenzonitrile. In addition to Nitroxynil, the herbicides ioxynil (3,5-diiodo) and bromoxynil (3,5-dibromo) were also invented by the same company. Nitroxynil has a nitro group in addition to a single iodine group.

Nitroxynil is almost insoluble in water. It is usually injected subcutaneously into the animals in the form of the water-soluble ethylglucamine salt.[2] It must not be administered to animals that produce milk for human consumption.[4]

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