Non-hallucinogenic 5-HT2A Agonist

Non-hallucinogenic psychedelics (NHPs) are a subclass of serotonergic psychedelics which putatively lack hallucinogenic effects while retaining the psychoplastogenic effects of classical psychedelics.^[1] In pre-clinical models, animals treated with non-hallucinogenic psychedelics exhibit fewer 5-HT_2A hallucinogen-associated behaviors at doses which produce rapid-acting antidepressant effects.^[1][2] The psychoplastogenic effects of non-hallucinogenic psychedelics coincide with their rapid-acting anti-depressant effects in animal models.^[3]

It has been suggested that non-hallucinogenic psychedelics may be more suitable for broader clinical use as compared to classical psychedelics due to their potentially reduced perception-altering effects.^[4]

Pharmacology

The mechanism by which non-hallucinogenic psychedelics exert their perception-sparing effects is unknown, although biased agonism at the 5-HT_2A receptor appears to be a prevalent hypothesis.^[5][6][7] Low intrinsic efficacy has also been proposed as a potential mechanism.^[8]

See also

• BMB-201
• Ariadne (drug)
• ITI-1549