Nucleoside-triphosphatase

In enzymology, a nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) is an enzyme that catalyzes the chemical reaction

NTP + H₂O ${\displaystyle \rightleftharpoons }$ NDP + phosphate

nucleoside-triphosphatase
Identifiers
EC no.	3.6.1.15
CAS no.	9075-51-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are NTP and H₂O, whereas its two products are NDP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and nucleoside 5-triphosphatase. This enzyme participates in purine metabolism and thiamine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I3B.