Nucleotide diphosphatase

In enzymology, a nucleotide diphosphatase (EC 3.6.1.9^{[dubious – discuss]}) is an enzyme that catalyzes the chemical reaction

a dinucleotide + H₂O ${\displaystyle \rightleftharpoons }$ 2 mononucleotides

nucleotide diphosphatase
Identifiers
EC no.	3.6.1.9
CAS no.	9032-64-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are dinucleotide and H₂O, whereas its product is mononucleotide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include nucleotide pyrophosphatase, and nucleotide-sugar pyrophosphatase. This enzyme participates in 5 metabolic pathways: purine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, and pantothenate and coa biosynthesis.

Structural studies

As of late 2007^[update], 5 structures have been solved for this class of enzymes, with PDB accession codes 1NQY, 1NQZ, 2GSN, 2GSO, and 2GSU.