OXSR1

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.^[5][6]

OXSR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V3S, 2VWI, 3DAK
Identifiers
Aliases	OXSR1, OSR1, oxidative stress responsive 1, oxidative stress responsive kinase 1
External IDs	OMIM: 604046; MGI: 1917378; HomoloGene: 31288; GeneCards: OXSR1; OMA:OXSR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,165,089 bp[1] End 38,255,484 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 119,067,498 bp[2] End 119,151,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Skeletal muscle tissue of rectus abdominis mucosa of pharynx body of tongue saphenous vein gastrocnemius muscle embryo ganglionic eminence glutes ventricular zone Top expressed in muscle of thigh skeletal muscle tissue genital tubercle quadriceps femoris muscle cumulus cell tail of embryo knee joint triceps brachii muscle ankle medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function magnesium ion binding protein kinase activity protein binding kinase activity metal ion binding nucleotide binding transferase activity ATP binding protein serine/threonine kinase activity identical protein binding protein kinase binding Cellular component extracellular exosome cytoplasm cytosol Biological process response to oxidative stress negative regulation of potassium ion transmembrane transport cellular hypotonic response phosphorylation negative regulation of potassium ion transmembrane transporter activity protein phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction regulation of mitotic cell cycle signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity regulation of apoptotic process osmosensory signaling pathway positive regulation of T cell chemotaxis chemokine (C-C motif) ligand 21 signaling pathway chemokine (C-X-C motif) ligand 12 signaling pathway protein autophosphorylation cellular response to chemokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9943 108737 Ensembl ENSG00000172939 ENSMUSG00000036737 UniProt O95747 Q6P9R2 RefSeq (mRNA) NM_005109 NM_133985 NM_001359582 RefSeq (protein) NP_005100 NP_598746 NP_001346511 Location (UCSC) Chr 3: 38.17 – 38.26 Mb Chr 9: 119.07 – 119.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.^[6]