NADPH dehydrogenase

In enzymology, a NADPH dehydrogenase (EC 1.6.99.1) is an enzyme that catalyzes the chemical reaction

NADPH + H⁺ + acceptor ${\displaystyle \rightleftharpoons }$ NADP⁺ + reduced acceptor

NADPH dehydrogenase
X-ray structure of Xenobiotic Reductase A from Pseudomonas putida. PDB entry 3l5l
Identifiers
EC no.	1.6.99.1
CAS no.	9001-68-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are NADPH, H⁺, and acceptor, whereas its two products are NADP⁺ and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with other acceptors. It has 2 cofactors: FAD, and FMN.

Nomenclature

The systematic name of this enzyme class is NADPH:acceptor oxidoreductase. Other names in common use include

• NADPH2 diaphorase
• NADPH diaphorase
• old yellow enzyme
• diaphorase
• dihydronicotinamide adenine dinucleotide phosphate dehydrogenase
• NADPH-dehydrogenase
• NADPH-diaphorase
• NADPH2-dehydrogenase
• reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
• TPNH dehydrogenase
• TPNH-diaphorase
• triphosphopyridine diaphorase
• triphosphopyridine nucleotide diaphorase
• NADPH2 dehydrogenase
• NADPH:(acceptor) oxidoreductase.