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Orotidine 5′-monophosphate

Chemical compound From Wikipedia, the free encyclopedia

Orotidine 5′-monophosphate
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Orotidine 5′-monophosphate (OMP), also known as orotidylic acid, is a pyrimidine nucleotide[1] which is the last intermediate in the biosynthesis of uridine monophosphate.[2] OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme orotate phosphoribosyltransferase.

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In humans, the enzyme UMP synthase converts OMP into uridine 5′-monophosphate.[2] If UMP synthase is defective, orotic aciduria can result.[2]

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