PCDH17

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.^[5][6]

PCDH17
Identifiers
Aliases	PCDH17, PCDH68, PCH68, protocadherin 17
External IDs	OMIM: 611760; MGI: 2684924; HomoloGene: 8700; GeneCards: PCDH17; OMA:PCDH17 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q21.1 Start 57,631,744 bp[1] End 57,729,311 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 84,681,003 bp[2] End 84,776,442 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell visceral pleura sperm Brodmann area 23 entorhinal cortex lower lobe of lung pars reticulata superior vestibular nucleus germinal epithelium ventral tegmental area Top expressed in lateral hypothalamus ventromedial nucleus dorsomedial hypothalamic nucleus anterior amygdaloid area mammillary body lateral septal nucleus paraventricular nucleus of hypothalamus ventral tegmental area arcuate nucleus supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane Biological process presynaptic active zone assembly adult behavior regulation of synaptic vesicle clustering negative regulation of synaptic transmission homophilic cell adhesion via plasma membrane adhesion molecules cell adhesion cell-cell signaling synapse assembly synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27253 219228 Ensembl ENSG00000118946 ENSMUSG00000035566 UniProt O14917 n/a RefSeq (mRNA) NM_001040429 NM_014459 NM_001013753 RefSeq (protein) NP_001035519 n/a Location (UCSC) Chr 13: 57.63 – 57.73 Mb Chr 14: 84.68 – 84.78 Mb PubMed search [3] [4]
Wikidata
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This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.^[6] PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy ^[7]