3',5'-cyclic-AMP phosphodiesterase

3′,5′-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase.^{[1][2][3][4][5][6]} It catalyses the following reaction

adenosine 3′,5′-cyclic phosphate + H₂O ${\displaystyle \rightleftharpoons }$ AMP

3′,5′-cyclic-AMP phosphodiesterase
Identifiers
EC no.	3.1.4.53
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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This enzyme requires Mg²⁺ or Mn²⁺ for activity.