Phosphoethanolamine/phosphocholine phosphatase

Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75, PHOSPHO1, 3X11A; systematic name phosphoethanolamine phosphohydrolase) is an enzyme highly expressed in mineralizing cells .^[1][2][3] This enzyme is implicated in bone and cartilage formation and catalyses the following chemical reactions:

(1) O-phosphoethanolamine + H₂O ${\displaystyle \rightleftharpoons }$ ethanolamine + phosphate

(2) phosphocholine + H₂O ${\displaystyle \rightleftharpoons }$ choline + phosphate

Phosphoethanolamine/phosphocholine phosphatase
Identifiers
EC no.	3.1.3.75
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme is a member of the haloacid dehalogenase superfamily. Like other members of this superfamily it requires a metal ion for catalysis, which is usually Mg²⁺, it is also active in the presence of Co²⁺ or Mn²⁺ but exhibits a lower specific activity with these metal ions.