Elafin

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.^[3][4][5]

PI3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1FLE, 2REL
Identifiers
Aliases	PI3, ESI, SKALP, WAP3, WFDC14, cementoin, peptidase inhibitor 3
External IDs	OMIM: 182257; HomoloGene: 122140; GeneCards: PI3; OMA:PI3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,174,902 bp[1] End 45,176,544 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis vulva nasal epithelium olfactory zone of nasal mucosa gums gingival epithelium minor salivary glands oral cavity mucosa of pharynx cervix epithelium n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity structural constituent of skin epidermis Cellular component extracellular region cytosol cornified envelope extracellular matrix Biological process negative regulation of peptidase activity copulation negative regulation of endopeptidase activity antimicrobial humoral response cornification peptide cross-linking Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5266 n/a Ensembl ENSG00000124102 n/a UniProt P19957 n/a RefSeq (mRNA) NM_002638 n/a RefSeq (protein) NP_002629 n/a Location (UCSC) Chr 20: 45.17 – 45.18 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.^[5]

Clinical significance

Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.^[6]

Elafin plays some role in gut inflammation. ^[7]