PRKRA

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.^[5][6][7] PACT heterodimerizes with and activates protein kinase R.^[6][8] PRKRA mutations have been linked to a rare form of dystonia parkinsonism.^[9]

PRKRA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIX
Identifiers
Aliases	PRKRA, DYT16, PACT, RAX, HSD14, protein activator of interferon induced protein kinase EIF2AK2
External IDs	OMIM: 603424; MGI: 1344375; HomoloGene: 2738; GeneCards: PRKRA; OMA:PRKRA - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.2 Start 178,431,292 bp[1] End 178,451,512 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 76,460,242 bp[2] End 76,478,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis right ventricle gastrocnemius muscle muscle of thigh thoracic diaphragm tibial arteries Descending thoracic aorta ganglionic eminence Top expressed in interventricular septum endocardial cushion medullary collecting duct fossa renal corpuscle medial ganglionic eminence condyle otic vesicle atrioventricular valve neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding identical protein binding enzyme binding double-stranded RNA binding enzyme activator activity RNA binding pre-miRNA binding Cellular component cytoplasm membrane intracellular anatomical structure nucleoplasm perinuclear region of cytoplasm cytosol RISC-loading complex Biological process skeletal system morphogenesis response to virus outer ear morphogenesis pre-miRNA processing protein phosphorylation immune response middle ear morphogenesis cellular response to oxidative stress positive regulation of intrinsic apoptotic signaling pathway negative regulation of cell population proliferation production of miRNAs involved in gene silencing by miRNA positive regulation of catalytic activity protein stabilization miRNA metabolic process production of siRNA involved in RNA interference gene silencing viral process ear development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8575 23992 Ensembl ENSG00000180228 ENSMUSG00000002731 UniProt O75569 Q9WTX2 RefSeq (mRNA) NM_001139517 NM_001139518 NM_001316362 NM_003690 NM_011871 RefSeq (protein) NP_001132989 NP_001132990 NP_001303291 NP_003681 NP_036001 Location (UCSC) Chr 2: 178.43 – 178.45 Mb Chr 2: 76.46 – 76.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse