Oxycodone/paracetamol

"Percocet" and "Percs" redirect here. For the band, see Percocettes. For the supercomputer technology, see PERCS. For the cleaning chemical PERC, see tetrachloroethylene.

Oxycodone/paracetamol, sold under the brand name Percocet among others,^[2] is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain.^[1]

Oxycodone/paracetamol

Combination of
Oxycodone	Opioid analgesic
Acetaminophen	Anilide analgesic
Clinical data
Trade names	Percocet, others
AHFS/Drugs.com	acetaminophen-and-oxycodone Professional Drug Facts
License data	US DailyMed: Oxycodone hydrochloride and acetaminophen
Routes of administration	By mouth
ATC code	N02AJ17 (WHO)
Legal status
Legal status	US: Schedule II[1]
Identifiers
CAS Number	330988-72-2 Y
ChemSpider	4881971 Y
KEGG	D02153
CompTox Dashboard (EPA)	DTXSID10186763
NY (what is this?)  (verify)

In 2022, it was the 98th most commonly prescribed medication in the United States, with more than 6 million prescriptions.^[3][4]

History

The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106.^[5]

Society and culture

Percocet is often called perc for short.^[6][7] As of 2018, it was often name-dropped in rap music, such as Future's song "Mask Off".^[6]

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics^[8] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage.^[9]

In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period.^[10][11][12]