Phloroisovalerophenone synthase

In enzymology, a phloroisovalerophenone synthase (EC 2.3.1.156) is an enzyme that catalyzes the chemical reaction

isovaleryl-CoA + 3 malonyl-CoA ${\displaystyle \rightleftharpoons }$ 4 CoASH + 3 CO₂ + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

phloroisovalerophenone synthase
Identifiers
EC no.	2.3.1.156
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are isovaleryl-CoA and malonyl-CoA, whereas its 3 products are CoASH, CO₂, and 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is isovaleryl-CoA:malonyl-CoA acyltransferase. Other names in common use include valerophenone synthase, and 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.