Phorbol-diester hydrolase

The enzyme phorbol-diester hydrolase (EC 3.1.1.51) catalyzes the reaction

phorbol 12,13-dibutanoate + H₂O ${\displaystyle \rightleftharpoons }$ phorbol 13-butanoate + butanoate

phorbol-diester hydrolase
Identifiers
EC no.	3.1.1.51
CAS no.	81181-74-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is 12,13-diacylphorbate 12-acylhydrolase. Other names in common use include diacylphorbate 12-hydrolase, diacylphorbate 12-hydrolase, phorbol-12,13-diester 12-ester hydrolase, and PDEH.