Phosducin

Phosducin, also known as PDC, is a human protein and gene.^[5] It belongs to the phosducin family of proteins.

PDC
Identifiers
Aliases	PDC, MEKA, PHD, PhLOP, PhLP, phosducin
External IDs	OMIM: 171490; MGI: 98090; HomoloGene: 1950; GeneCards: PDC; OMA:PDC - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q31.1 Start 186,443,566 bp[1] End 186,461,114 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G1|1 63.84 cM Start 150,195,168 bp[2] End 150,209,657 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle retinal pigment epithelium right hemisphere of cerebellum corpus callosum epithelium of colon Achilles tendon Brodmann area 9 skin of hip tibial nerve striated muscle tissue Top expressed in neural layer of retina retinal pigment epithelium epithelium of lens ciliary body corneal stroma iris pineal gland gallbladder conjunctival fornix internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phospholipase inhibitor activity queuine tRNA-ribosyltransferase activity Cellular component photoreceptor inner segment cytoplasm cytosol photoreceptor outer segment cell projection cilium nucleus Biological process queuosine biosynthetic process G protein-coupled receptor signaling pathway response to stimulus visual perception phototransduction negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5132 20028 Ensembl ENSG00000116703 ENSMUSG00000006007 UniProt P20941 Q52LP8 Q9QW08 RefSeq (mRNA) NM_002597 NM_022576 NM_022577 NM_001159730 NM_024458 RefSeq (protein) NP_002588 NP_072098 NP_002588.3 NP_001153202 NP_077778 Location (UCSC) Chr 1: 186.44 – 186.46 Mb Chr 1: 150.2 – 150.21 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. By associating with these subunits only, the transducin alpha subunit will remain active for longer. This will increase the amount of time of visual excitation.

This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

See also

• Phosducin family