Phosphate acetyltransferase

In enzymology, a phosphate acetyltransferase (EC 2.3.1.8) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + phosphate ${\displaystyle \rightleftharpoons }$ CoA + acetyl phosphate

Phosphate acetyltransferase
Phosphate acetyltransferase homodimer, Methanosarcina thermophila
Identifiers
EC no.	2.3.1.8
CAS no.	9029-91-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The substrates of this enzyme are acetyl-CoA and phosphate, whereas its two products are CoA and acetyl phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:phosphate acetyltransferase. Other names in common use include phosphotransacetylase, phosphoacylase, and PTA. This enzyme participates in 3 metabolic pathways: taurine and hypotaurine metabolism, pyruvate metabolism, and propanoate metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1QZT, 1R5J, 1TD9, 1VMI, 1XCO, 2AF3, and 2AF4.