Phosphatidyl-N-methylethanolamine N-methyltransferase

In enzymology, a phosphatidyl-N-methylethanolamine N-methyltransferase (EC 2.1.1.71) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine

phosphatidyl-N-methylethanolamine N-methyltransferase
Identifiers
EC no.	2.1.1.71
CAS no.	67167-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are S-adenosyl methionine and phosphatidyl-N-methylethanolamine, whereas its two products are S-adenosylhomocysteine and phosphatidyl-N-dimethylethanolamine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase. Other names in common use include phosphatidylmonomethylethanolamine methyltransferase, methyltransferase II, phospholipid methyltransferase, PLMT, phosphatidyl-N-methylethanolamine methyltransferase, phosphatidyl-N-monomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase I, and phosphatidylmonomethylethanolamine methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism.