Phosphatidylinositol-3-phosphatase

The enzyme phosphatidylinositol-3-phosphatase (EC 3.1.3.64) catalyzes the reaction

1-phosphatidyl-1D-myo-inositol 3-phosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1-phosphatidyl-1D-myo-inositol + phosphate

phosphatidylinositol-3-phosphatase
Identifiers
EC no.	3.1.3.64
CAS no.	124248-47-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase. Other names in common use include inositol-1,3-bisphosphate 3-phosphatase, inositol 1,3-bisphosphate phosphatase, inositol-polyphosphate 3-phosphatase, D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase, and phosphatidyl-3-phosphate 3-phosphohydrolase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LW3 and 1M7R.