Phosphogluconate dehydratase

The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction

6-phospho-D-gluconate ${\displaystyle \rightleftharpoons }$ 2-dehydro-3-deoxy-6-phospho-D-gluconate + H₂O

phosphogluconate dehydratase
6-Phosphogluconate dehydratase monomer, Shewanella oneidensis
Identifiers
EC no.	4.2.1.12
CAS no.	9024-33-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-Dgluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.