Phosphoglucosamine mutase

In enzymology, a phosphoglucosamine mutase (EC 5.4.2.10) is an enzyme that catalyzes the chemical reaction

alpha-D-glucosamine 1-phosphate ${\displaystyle \rightleftharpoons }$ D-glucosamine 6-phosphate

Identifiers
EC no.	5.4.2.10
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, alpha-D-glucosamine 1-phosphate, and one product, D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (α-D-phosphohexomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism.

Crystal structures of two bacterial phosphoglucosamine mutases are known (PDB entries 3I3W and 3PDK), from Francisella tularensis and Bacillus anthracis. Both share a similar dimeric quaternary structure, as well as conserved features of the active site, as found their enzyme superfamily, the α-D-phosphohexomutases.