Phosphonate dehydrogenase

In enzymology, a phosphonate dehydrogenase (EC 1.20.1.1) is an enzyme that catalyzes the chemical reaction

phosphonate + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ phosphate + NADH + H⁺

phosphonate dehydrogenase
Identifiers
EC no.	1.20.1.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are phosphonate, NAD⁺, and H₂O, whereas its 3 products are phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phosphonate:NAD+ oxidoreductase. Other names in common use include NAD:phosphite oxidoreductase, and phosphite dehydrogenase.